| Full name: | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase |
|---|---|
| UniProt: | O42662 |
| Enzyme type: | |
| Position of modification - modification: |
n:43 - m6A |
| Level of experimental evidence: | 2 |
| Level of experimental reliability: | 2 |
MPIYILIERSVKNGRIDFWNEDAIRTLGKAILDRDYSLRVEFPENRLCPMVPNRATYIRYIHDLLSSTSGQKDKKRIIGLDIGTGASCIYPLLGCRMYSYDFVGTEIDKFSFETAKSNILQNNMESQIKIVLRSKQDCLLPDTEGMEEFTFVMCNPPFYEHEEDFINFKQNPPSGVCTGVYHEMVTEGGEVGFANKILTESKKRKGIQWYTCMFGKKSSVPAVVDKLREQNISNYGIYELALGKTKRWIICWSFQAMRPHNELIRPSSTSLSKYFPHKVLQNWTLDPELCAQIDDILQKFLDDNKIPWSKKGSVLEISTKSITWSRKARRISKSQTSVSSLEGQMKCELNVIDNQLQCKWIEGYDYNVYESFCSALARALRDNKK
METTL16 m6A methylates MAT2A hairpins and the spliceosomal U6 snRNA.
| Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
|---|---|---|---|---|---|---|---|---|---|---|
| A:m6A | snRNA (sn) | snRNA/snRNA/eukaryotic nucleoplasm | 43 |
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention | Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK | Cell | [details] | 28525753 | 10.1016/j.cell.2017.05.003 |
| Structures and mechanisms of U6 snRNA m<sup>6</sup>A modification by METTL16. | Ju J; Tomita K | Nat Commun | [details] | 40841561 | 10.1038/s41467-025-63021-0 |