Modomics - A Database of RNA Modifications

ID Card:

Full name: Trimethylguanosine synthase 1
Synonym: P2573
GI: 74583797
Orf: YPL157W
COG: COG0116
UniProt: Q12052
Alpha Fold Predicted Structure: AF-Q12052-F1
Enzyme type: methyltransferase
Position of modification - modification: n:0 - m2,2,7GpppN
snoRNA:0 - m2,2,7GpppN



Protein sequence:

MGRTFIHASKIKHAARKRKHHSNFRTLIKLLNNDAYKIESSKPLKNGKLFKYWKNRRRLFSKIDSASIYMTDELWFSVTPERIACFLANFVKACMPNAERILDVFCGGGGNTIQFAMQFPYVYGVDYSIEHIYCTAKNAQSYGVDDRIWLKRGSWKKLVSKQKLSKIKYDCVFGSPPWGGPEYLRNDVYDLEQHLKPMGITKMLKSFLKLSPNVIMFLPRNSDLNQLSRATRKVLGPFAKCKVLYVKENGYMKGIFCMWGECFFNYEPASTENSRRESSEKEELSSENEELSKRKKHESTTTTKDNTVDIYDVNG

Comments:

Tgs1p is an evolutionarily conserved protein that carries a signature of S-AdoMet methyltransferase and is essential for hypermethylation of the m(7)G caps of both snRNAs and snoRNAs (Mouaikel et al. 2002 ). The absence of Tgs1 caused changes in telomere length and structure, improved telomeric silencing and stabilized telomeric recombination. Moreover, the yeast snRNA and snoRNA methyltransferase Tgs1 is responsible for TLC1 m3G cap formation (Franke et al. 2008 ).





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M G R T F I H A S K I K H A A R K R K H H S N F R T L I K L L N N D A Y K I E S S K P L K N G K L F K Y W K N R R R L F S K I D S A S I Y M T D E L W F S V T P E R I A C F L A N F V K A C M P N A E R I L D V F C G G G G N T I Q F A M Q F P Y V Y G V D Y S I E H I Y C T A K N A Q S Y G V D D R I W L K R G S W K K L V S K Q K L S K I K Y D C V F G S P P W G G P E Y L R N D V Y D L E Q H L K P M G I T K M L K S F L K L S P N V I M F L P R N S D L N Q L S R A T R K V L G P F A K C K V L Y V K E N G Y M K G I F C M W G E C F F N Y E P A S T E N S R R E S S E K E E L S S E N E E L S K R K K H E S T T T T K D N T V D I Y D V N G
50100150200250300SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q12052-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q12052-F1.cif  
DSSP Secondary Structures   Q12052.dssp  





Publications: