Comments:

AdoMet is the methyl group donor. Carries out N2-dimethylation of m7G cap in snRNA and snoRNA. Involved in telomere regulation; m3G cap formation of the telomerase RNA TLC1 depends on Tgs1.

Protein sequence:

Enzymatic activities:

Reaction	Substrate	Type	Position
m7G:m2,7G	snoRNA (sno)		1
m2,7G:m2,2,7G	snoRNA (sno)		1
m7G:m2,7G	snRNA (sn)		1
m2,7G:m2,2,7G	snRNA (sn)		1

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1).	Hausmann S, Shuman S	J Biol Chem	[details]	15590684	-
Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus.	Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonne R	Mol Cell	[details]	11983179	-
Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase.	Mouaikel J, Bujnicki JM, Tazi J, Bordonne R	Nucleic Acids Res	[details]	12907733	-
Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1.	Franke J, Gehlen J, Ehrenhofer-Murray AE	J Cell Sci	[details]	18840651	-

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