ID Card:
| Full name: |
tRNA-uridine aminocarboxypropyltransferase 1 |
| UniProt: |
Q8N5C7 |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - acp3U
|
| Level of experimental evidence: |
2 |
| Level of experimental reliability: |
2 |
Protein sequence:
MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVKLPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH
Comments:
DTWD1 is responsible for the formation of acp3U at position 20 of tRNAs. In human cells, double knockout of DTWD1 and DTWD2 (acp3U at U20a) causes slow growth, indicating that acp3U is also physiologically important in mammals
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
U:acp3U
|
tRNA (t) |
tRNA/tRNA/eukaryotic nucleoplasm |
20 |
|
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Biogenesis and functions of aminocarboxypropyluridine in tRNA. |
Takakura M; Ishiguro K; Akichika S; Miyauchi K; Suzuki T |
Nat Commun |
[details]
|
31804502
|
10.1038/s41467-019-13525-3
|