ID Card:
| Full name: |
tRNA-uridine aminocarboxypropyltransferase 2 |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - acp3U
|
| Level of experimental evidence: |
2 |
| Level of experimental reliability: |
2 |
Protein sequence:
Comments:
DTWD2 is responsible for the formation of acp3U at position 20a of tRNA. In human cells, double knockout of DTWD1 (acp3U at U20) and DTWD2 causes slow growth, indicating that acp3U is also physiologically important in mammals
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
U:acp3U
|
tRNA (t) |
tRNA/tRNA/eukaryotic nucleoplasm |
20 |
|
|
|
|
|
|
|
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Biogenesis and functions of aminocarboxypropyluridine in tRNA. |
Takakura M; Ishiguro K; Akichika S; Miyauchi K; Suzuki T |
Nat Commun |
[details]
|
31804502
|
10.1038/s41467-019-13525-3
|