ID Card:
| Full name: |
23S rRNA 5-hydroxycytidine C2501 synthase |
| Synonym: |
ydcP |
| UniProt: |
P76104 |
| Enzyme type: |
|
| Position of modification - modification: |
:2501(None) - ho5C
|
| Level of experimental evidence: |
3 |
| Level of experimental reliability: |
2 |
Protein sequence:
MTVSSHRLELLSPARDAAIAREAILHGADAVYIGGPGFGARHNASNSLKDIAELVPFAHRYGAKIFVTLNTILHDDELEPAQRLITDLYQTGVDALIVQDMGILELDIPPIELHASTQCDIRTVEKAKFLSDVGFTQIVLARELNLDQIRAIHQATDATIEFFIHGALCVAYSGQCYISHAQTGRSANRGDCSQACRLPYTLKDDQGRVVSYEKHLLSMKDNDQTANLGALIDAGVRSFKIEGRYKDMSYVKNITAHYRQMLDAIIEERGDLARASSGRTEHFFVPSTEKTFHRGSTDYFVNARKGDIGAFDSPKFIGLPVGEVVKVAKDHLDVAVTEPLANGDGLNVLIKREVVGFRANTVEKTGENQYRVWPNEMPADLHKIRPHHPLNRNLDHNWQQALTKTSSERRVAVDIELGGWQEQLILTLTSEEGVSITHTLDGQFDEANNAEKAMNNLKDGLAKLGQTLYYARDVQINLPGALFVPNSLLNQFRREAADMLDAARLASYQRGSRKPVADPAPVYPQTHLSFLANVYNQKAREFYHRYGVQLIDAAYEAHEEKGEVPVMITKHCLRFAFNLCPKQAKGNIKSWKATPMQLVNGDEVLTLKFDCRPCEMHVIGKIKNHILKMPLPGSVVASVSPDELLKTLPKRKG
Comments:
Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position of 23S rRNA. May be a Fe-S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
C:ho5C
|
rRNA (r) |
rRNA/rRNA/prokaryotic cytosol |
2501 |
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Biogenesis and iron-dependency of ribosomal RNA hydroxylation. |
Kimura S; Sakai Y; Ishiguro K; Suzuki T |
Nucleic Acids Res |
[details]
|
29069499
|
10.1093/nar/gkx969
|