| Full name: | Archaeosine synthase |
|---|---|
| Synonym: | HVO_2008 |
| UniProt: | D4GTN6 |
| Enzyme type: | |
| Position of modification - modification: |
t:None - G+ |
| Level of experimental evidence: | 3 |
| Level of experimental reliability: | 2 |
nan
arcS is responsible for the final step in the biosynthesis of archaeosine in the dihydrouridine loop (D-loop). Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0) to archaeosine, transforming a nitrile group to a formamidine group.
| Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
|---|---|---|---|---|---|---|---|---|---|---|
| preQ0:G+ | tRNA (t) | tRNA/tRNA/prokaryotic cytosol | 15 |
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA. | Phillips G, Chikwana VM, Maxwell A, El-Yacoubi B, Swairjo MA, Iwata-Reuyl D, de Crecy-Lagard V... | J Biol Chem | [details] | 20129918 | - |
| A Gateway platform for functional genomics in Haloferax volcanii: deletion of three tRNA modification genes. | El Yacoubi B; Phillips G; Blaby IK; Haas CE; Cruz Y; Greenberg J; de Crécy-Lagard V | Archaea | [details] | 19478918 | - |