Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA 4-thiouridine(8) synthase
Synonym: NuvA
GI: 2501549
Orf: b0423
COG: COG0301
UniProt: P77718
Alpha Fold Predicted Structure: AF-P77718-F1
Enzyme type: sulfurtransferase
Position of modification - modification: t:8 - s4U



Protein sequence:

MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSIDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNKTWLLWCERGVMSRLQALYLREQGFNNVKVYRP

Comments:

Requires IcsS as a sulphur donor. Thiamine biosyntheses protein. Contains 1 rhodanese domain. Sulfur is transferred to ThiI through direct binding of IscS. ThiI then transfers the sulfur group to the conserved U8 of bacterial tRNA to form s4U8.





Alpha Fold Predicted Structure:




Parsing response... [446525/446525]


Clear Selection and Reset Camera

Protein sequence:

M K F I I K L F P E I T I K S Q S V R L R F I K I L T G N I R N V L K H Y D E T L A V V R H W D N I E V R A K D E N Q R L A I R D A L T R I P G I H H I L E V E D V P F T D M H D I F E K A L V Q Y R D Q L E G K T F C V R V K R R G K H D F S S I D V E R Y V G G G L N Q H I E S A R V K L T N P D V T V H L E V E D D R L L L I K G R Y E G I G G F P I G T Q E D V L S L I S G G F D S G V S S Y M L M R R G C R V H Y C F F N L G G A A H E I G V R Q V A H Y L W N R F G S S H R V R F V A I N F E P V V G E I L E K I D D G Q M G V I L K R M M V R A A S K V A E R Y G V Q A L V T G E A L G Q V S S Q T L T N L R L I D N V S D T L I L R P L I S Y D K E H I I N L A R Q I G T E D F A R T M P E Y C G V I S K S P T V K A V K S K I E A E E E K F D F S I L D K V V E E A N N V D I R E I A Q Q T E Q E V V E V E T V N G F G P N D V I L D I R S I D E Q E D K P L K V E G I D V V S L P F Y K L S T K F G D L D Q N K T W L L W C E R G V M S R L Q A L Y L R E Q G F N N V K V Y R P
50100150200250300350400450SequenceGHITSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P77718-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P77718-F1.cif  
DSSP Secondary Structures   P77718.dssp  





Publications:

Links:

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