Modomics - A Database of RNA Modifications

Full name: tRNA pseudouridine synthase 3
Synonym: Deg1p, Hrm3
GI: 399356
Orf: YFL001W
COG: COG0101
UniProt: P31115
Structures: | |
Complex:
Enzyme type: pseudouridine synthase
Position of modification - modification: t:39 - Y
t:38 - Y

Comments:

Region specificity.Monomeric enzyme.

Protein sequence:

MSNFIRRLVGKMKAISTGTNAIVSKKDSIYANWSKEQLIRRITELENANKPHSEKFQHIEDNKKRKISQEEVTRSKAKKAPKKFDFSKHNTRFIALRFAY
LGWNYNGLAVQKEYTPLPTVEGTILEAMNKCKLVPSMVLQDYKFSRCGRTDKGVSAMNQVISLEVRSNLTDEEQRDPTNDSREIPYVHVLNQLLPDDIRI
SAVCLRPPPNFDARFSCVHRHYKYIFNGKNLNIEKMSKAASYFVGERDFRNFCKLDGSKQITNFKRTIISSKILPLSETFYCFDLVGSAFLWHQVRCMMA
ILFLVGQSLEVPEIVLRLTDIEKTPQRPVYEMANDIPLLLYDCKFPEMDWQEPTVDDYKAIKFTTATEALTLHYELKAAVCNIFKDVLPTANTNNFSKTI
INLGDGRGKVVGTYVKLEDRSVMEPVEVVNAKYSKKKNNKNK

Enzymatic activities:

Reaction Substrate Type Position
U:Y tRNA (t) Ala/IGC/prokaryotic cytosol 38
U:Y tRNA (t) Gly/GCC/prokaryotic cytosol 38
U:Y tRNA (t) Arg/ACU/prokaryotic cytosol 39
U:Y tRNA (t) Asn/GUU/prokaryotic cytosol 39
U:Y tRNA (t) Cys/GCA/prokaryotic cytosol 39
U:Y tRNA (t) His/GUG/prokaryotic cytosol 39
U:Y tRNA (t)   39
U:Y tRNA (t) Leu/CAA/prokaryotic cytosol 39
U:Y tRNA (t)   39
U:Y tRNA (t) Lys/CUU/prokaryotic cytosol 39
U:Y tRNA (t) Met/CAU/prokaryotic cytosol 39
U:Y tRNA (t) Phe/GAA/prokaryotic cytosol 39
U:Y tRNA (t) Ser/CGA/prokaryotic cytosol 39
U:Y tRNA (t) Ser/UGA/prokaryotic cytosol 39
U:Y tRNA (t) Ser/IGA/prokaryotic cytosol 39
U:Y tRNA (t) Thr/IGU/prokaryotic cytosol 39
U:Y tRNA (t) Trp/CCA/prokaryotic cytosol 39
U:Y tRNA (t) Tyr/GUA/prokaryotic cytosol 39
U:Y tRNA (t) His/GUG/mitochondrion 38
U:Y tRNA (t) Thr/UAG/mitochondrion 38
U:Y tRNA (t) Arg/UCU/mitochondrion 39
U:Y tRNA (t) Arg/ACG/mitochondrion 39
U:Y tRNA (t) Leu/UAA/mitochondrion 39
U:Y tRNA (t) Phe/GAA/mitochondrion 39
U:Y tRNA (t) Ser/UGA/mitochondrion 39
U:Y tRNA (t) Trp/UCA/mitochondrion 39

Publications:

Title Authors Journal Details PubMed Id DOI
Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop. Lecointe F, Simos G, Sauer A, Hurt EC, Motorin Y, Grosjean H J Biol Chem [details] 9430663 -

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