Modomics - A Database of RNA Modifications

Full name:	Pseudouridylate synthase 6
Synonym:
GI:	1723726
Orf:	YGR169C
COG:	COG0564
UniProt:	P53294
Structures:	\| \|
Complex:
Enzyme type:	pseudouridine synthase
Position of modification - modification:	t:31 - Y

Comments:

Mitochondrial and cytoplasmatic tRNA.

Protein sequence:

MSTIKVIEVYTQNGLRKVRPYYNRRSAFVKGRWLGKLLIDVLVSEFKLRPRAYYLDQIRKGTYRLIRDGVPLVPDHLMTTIIKNHDVLETTTHKHEPPVK
QWCSQEVEAEDLPGRIAGFNIVFEDESILVIDKPSGIPVHPTGQFYQNTITELLKLHGVDALPCYRLDKITSGLLILAKNSQSAGEIQKSIRSRDMIKIY
LARVKGRFPHSELILDNENAAETTFEDTSKVTVEMTPIYSIDPKRQFPVGLSTSKDAITKFYPIRYFSHADETVVACKPITGRTHQIRIHLARLGHPIVN
DSVYCSHITKYPERLKFITQFPRWENQQDLDAEELKVRFQKFVDETKNNCRTMETFCPECHTVDLKDPVLSDLELWLHAWKYEEINGKFKFKTDLPKWAQ
LDNS

Enzymatic activities:

Reaction	Substrate	Type	Position
U:Y	tRNA (t)	Met/CAU/prokaryotic cytosol	31
U:Y	tRNA (t)	Gly/UCC/mitochondrion	31
U:Y	tRNA (t)	Ile/GAU/mitochondrion	31
U:Y	tRNA (t)	Leu/UAA/mitochondrion	31
U:Y	tRNA (t)	Lys/UUU/mitochondrion	31
U:Y	tRNA (t)		31
U:Y	tRNA (t)	Ser/GCU/mitochondrion	31
U:Y	tRNA (t)	Thr/UAG/mitochondrion	31

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Identification and characterization of the tRNA:Psi 31-synthase (Pus6p) of Saccharomyces cerevisiae.	Ansmant I, Motorin Y, Massenet S, Grosjean H, Branlant C	J Biol Chem	[details]	11406626	-