Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA guanosine-2′-O-methyltransferase TRM11
GI: 74655048
Orf: YOL124C
COG: COG1041
UniProt: Q12463
Alpha Fold Predicted Structure: AF-Q12463-F1
Enzyme type: methyltransferase
Position of modification - modification: t:10 - m2G



Protein sequence:

MKKYLLYMVQVHLNFRRAELESLADLYNLSIDFSQYDANSPFFIVELENDQQAKDWIKRSILTRGIYEYWGQGTTLDELHKDIQRQSNFEQDLQLKFKHSTFKFEFECYKGNSKAKRVEQIETFRYLGFEGKIDMKHPQEVFTVIEEYTPISENVGGKTPTRIYFGRQVQMSNRSAMEKYDLKKRPYKGTTSFEAELSLVSANIAQVKPGTIMYDPFAGTGSFLVAGGHFGSLVIGSDIDGRMIRGKGAQVNISANFKKYGESSQFLDVLTMDFTNNALRNNLVIDTILCDPPYGIRESIKVLGAKDPERFLGKEDMEIDGEKAYLRRDYIPTKKPYALDSLLDDLLQYSSERLPIGGRLAFWMPTANDANIETIVPMHENLELKYNCVQEFNKWSRRLLVYINRGSTFNGSSNHGIKRSKDNFRERYFNNFN

Comments:

AdoMet is the methyl group donor. Heterodimer composed of two unrelated subunits: Trm11p (catalytic subunit) and Trm112p (essential cofactor). Contains a THUMP domain.




Reaction Substrate SubstrateType Position (Anti)Codon Modified (Anti)Codon Amino Acid Change Transcript Name Transcript Region Cellular Localization References
G:m2G RNA tRNA 10 ACU ACU tRNAArgACU D-stem loop Cytoplasm
G:m2G RNA tRNA 10 ICG ICG tRNAArgICG D-stem loop Cytoplasm
G:m2G RNA tRNA 10 GUU GUU tRNAAsnGUU D-stem loop Cytoplasm
G:m2G RNA tRNA 10 IAU IAU tRNAIleIAU D-stem loop Cytoplasm
G:m2G RNA tRNA 10 UAU UAU tRNAIleUAU D-stem loop Cytoplasm
G:m2G RNA tRNA 10 UAG UAG tRNALeuUAG D-stem loop Cytoplasm
G:m2G RNA tRNA 10 CAA CAA tRNALeuCAA D-stem loop Cytoplasm
G:m2G RNA tRNA 10 UAA UAA tRNALeuUAA D-stem loop Cytoplasm
G:m2G RNA tRNA 10 CUU CUU tRNALysCUU D-stem loop Cytoplasm
G:m2G RNA tRNA 10 CAU CAU tRNAMetCAU D-stem loop Cytoplasm
G:m2G RNA tRNA 10 GAA GAA tRNAPheGAA D-stem loop Cytoplasm
G:m2G RNA tRNA 10 IGU IGU tRNAThrIGU D-stem loop Cytoplasm
G:m2G RNA tRNA 10 CCA CCA tRNATrpCCA D-stem loop Cytoplasm 15899842   
G:m2G RNA tRNA 10 GUA GUA tRNATyrGUA D-stem loop Cytoplasm 15899842   
G:m2G RNA tRNA 10 CAC CAC tRNAValCAC D-stem loop Cytoplasm 15899842   
G:m2G RNA tRNA 10 UAC UAC tRNAValUAC D-stem loop Cytoplasm 15899842   

Alpha Fold Predicted Structure:




Sequence of
1    ​M​​K​​K​​Y​​L​​L​​Y​​M​​V​​Q​11   ​V​​H​​L​​N​​F​​R​​R​​A​​E​​L​21   ​E​​S​​L​​A​​D​​L​​Y​​N​​L​​S​31   ​I​​D​​F​​S​​Q​​Y​​D​​A​​N​​S​41   ​P​​F​​F​​I​​V​​E​​L​​E​​N​​D​51   ​Q​​Q​​A​​K​​D​​W​​I​​K​​R​​S​61   ​I​​L​​T​​R​​G​​I​​Y​​E​​Y​​W​71   ​G​​Q​​G​​T​​T​​L​​D​​E​​L​​H​81   ​K​​D​​I​​Q​​R​​Q​​S​​N​​F​​E​91   ​Q​​D​​L​​Q​​L​​K​​F​​K​​H​​S​101  ​T​​F​​K​​F​​E​​F​​E​​C​​Y​​K​111  ​G​​N​​S​​K​​A​​K​​R​​V​​E​​Q​121  ​I​​E​​T​​F​​R​​Y​​L​​G​​F​​E​131  ​G​​K​​I​​D​​M​​K​​H​​P​​Q​​E​141  ​V​​F​​T​​V​​I​​E​​E​​Y​​T​​P​151  ​I​​S​​E​​N​​V​​G​​G​​K​​T​​P​161  ​T​​R​​I​​Y​​F​​G​​R​​Q​​V​​Q​171  ​M​​S​​N​​R​​S​​A​​M​​E​​K​​Y​181  ​D​​L​​K​​K​​R​​P​​Y​​K​​G​​T​191  ​T​​S​​F​​E​​A​​E​​L​​S​​L​​V​201  ​S​​A​​N​​I​​A​​Q​​V​​K​​P​​G​211  ​T​​I​​M​​Y​​D​​P​​F​​A​​G​​T​221  ​G​​S​​F​​L​​V​​A​​G​​G​​H​​F​231  ​G​​S​​L​​V​​I​​G​​S​​D​​I​​D​241  ​G​​R​​M​​I​​R​​G​​K​​G​​A​​Q​251  ​V​​N​​I​​S​​A​​N​​F​​K​​K​​Y​261  ​G​​E​​S​​S​​Q​​F​​L​​D​​V​​L​271  ​T​​M​​D​​F​​T​​N​​N​​A​​L​​R​281  ​N​​N​​L​​V​​I​​D​​T​​I​​L​​C​291  ​D​​P​​P​​Y​​G​​I​​R​​E​​S​​I​301  ​K​​V​​L​​G​​A​​K​​D​​P​​E​​R​311  ​F​​L​​G​​K​​E​​D​​M​​E​​I​​D​321  ​G​​E​​K​​A​​Y​​L​​R​​R​​D​​Y​331  ​I​​P​​T​​K​​K​​P​​Y​​A​​L​​D​341  ​S​​L​​L​​D​​D​​L​​L​​Q​​Y​​S​351  ​S​​E​​R​​L​​P​​I​​G​​G​​R​​L​361  ​A​​F​​W​​M​​P​​T​​A​​N​​D​​A​371  ​N​​I​​E​​T​​I​​V​​P​​M​​H​​E​381  ​N​​L​​E​​L​​K​​Y​​N​​C​​V​​Q​391  ​E​​F​​N​​K​​W​​S​​R​​R​​L​​L​401  ​V​​Y​​I​​N​​R​​G​​S​​T​​F​​N​411  ​G​​S​​S​​N​​H​​G​​I​​K​​R​​S​421  ​K​​D​​N​​F​​R​​E​​R​​Y​​F​​N​431  ​N​​F​​N​


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Protein sequence:

M K K Y L L Y M V Q V H L N F R R A E L E S L A D L Y N L S I D F S Q Y D A N S P F F I V E L E N D Q Q A K D W I K R S I L T R G I Y E Y W G Q G T T L D E L H K D I Q R Q S N F E Q D L Q L K F K H S T F K F E F E C Y K G N S K A K R V E Q I E T F R Y L G F E G K I D M K H P Q E V F T V I E E Y T P I S E N V G G K T P T R I Y F G R Q V Q M S N R S A M E K Y D L K K R P Y K G T T S F E A E L S L V S A N I A Q V K P G T I M Y D P F A G T G S F L V A G G H F G S L V I G S D I D G R M I R G K G A Q V N I S A N F K K Y G E S S Q F L D V L T M D F T N N A L R N N L V I D T I L C D P P Y G I R E S I K V L G A K D P E R F L G K E D M E I D G E K A Y L R R D Y I P T K K P Y A L D S L L D D L L Q Y S S E R L P I G G R L A F W M P T A N D A N I E T I V P M H E N L E L K Y N C V Q E F N K W S R R L L V Y I N R G S T F N G S S N H G I K R S K D N F R E R Y F N N F N
50100150200250300350400SequenceGHITBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q12463-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q12463-F1.cif  
DSSP Secondary Structures   Q12463.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B Mol Cell Biol [details] 15899842 -