Published on April 21, 2018 in Cancer Invest volume 36(4).

PubMed ID: 29775108

DOI: 10.1080/07357907.2018.1466896

Abstract:

NSUN2 is a tRNA methyltransferase and plays an important role in cell developmentvia modifying RNA methylation. We aimed to evaluate the expression of NSUN2 and itsprognostic value in HNSCC. Random-effects model of meta-analysis shows 1.99-folds(95% CI: 1.89-2.09) upregulation of NSUN2 expression in HNSCC versus normal tissues.Patients with high NSUN2 levels had approximately 22 months shorter overallsurvival, and had a higher mortality risk than those with low one (p-trend = 0.020).In conclusion, NSUN2 is a potential independent prognostic marker and may be apotential therapeutic target in HNSCC.