Published on Jan. 1, 2018 in Cancer Biomark volume 21(4).

PubMed ID: 29439311

DOI: CBM170791

Abstract:

In China, hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer andthe leading cause of cancer death in men, followed by lung and stomach cancer. Therewas an urgent need to identify novel prognostic biomarkers for HCC. We explored theexpression pattern of m6A related proteins in HCC tissues by using TCGA in thisstudy. We found that the m6A 'reader' YTHDF1 was significantly upregulated in HCCand was positive correlated with pathology stage. Kaplan-Meier analysis showed thatLower YTHDF1 expression level was associated with better survival of HCC patients.Furthermore, we performed GO and KEGG pathway analysis of YTHDF1 co-expressed genesand found YTHDF1 played an important role in regulating HCC cell cycle progressionand metabolism. We believed that this study will provide a potential new therapeuticand prognostic target for HCC.