Published on None in volume (2020) J Chem Inf Model 60: 5932-5935 .

PubMed ID: 33073985

DOI: 10.1021/acs.jcim.0c01029

Abstract:

Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N 6 -methyladenosine (m 6 A) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with m 6 A-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the m 6 A-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.