Modomics - A Database of RNA Modifications

IUPAC Name tert‑butyldimethylsilyl
Protecting group 2'-ribose
Deprotection fluoride labile
Synthesis reagent tert‑butyldimethylsilyl chloride

Protection group:

Can be found in the following building blocks:

1-methyladenosine 15763-06-1
1-methylguanosine 2140-65-0
2-methyladenosine 16526-56-0
2-methylthio-N6-isopentenyladenosine 20859-00-1
2-methylthio-N6-methyladenosine 13406-51-4
2-methylthio-N6-threonyl carbamoyladenosine 24719-82-2
2-thiouridine 20235-78-3
4-thiouridine 13957-31-8
5-hydroxycytidine 39638-73-8
5-methoxycarbonylmethyl-2-thiouridine 20299-15-4
5-methoxycarbonylmethyluridine 29428-50-0
5-methylaminomethyl-2-thiouridine 32860-54-1
5-methylaminomethyluridine 72667-55-1
5-methylcytidine (BB2) 2140-61-6
5-methyluridine 1463-10-1
5-taurinomethyluridine 497258-53-4
N4-acetylcytidine (BB1) 3768-18-1
N4-acetylcytidine (BB3) 3768-18-1
N6-isopentenyladenosine (BB2) 7724-76-7
N6-methyladenosine (BB3) 1867-73-8
N6-threonylcarbamoyladenosine 24719-82-2
N6-threonylcarbamoyladenosine (BB2) 24719-82-2
dihydrouridine 5627-05-4
inosine 58-63-9
pseudouridine (BB2) 1445-07-4


Title Authors Journal Details PubMed Id DOI
Solid phase synthesis of the 5'-half of the initiator t-RNA from B. subtilis. Chaix C, Duplaa AM, Molko D, Teoule R Nucleic Acids Res [details] 2508060 -
Chemical synthesis of a biologically active natural tRNA with its minor bases. Gasparutto D, Livache T, Bazin H, Duplaa AM, Guy A, Khorlin A, Molko D, Roget A, Teoule R Nucleic Acids Res [details] 1383941 -
Site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry. Agris PF, Malkiewicz A, Kraszewski A et al. Biochimie [details] 7599270 10.1016/0300-9084(96)88115-6
Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability. Kumar RK, Davis DR Nucleic Acids Res [details] 9092639 10.1093/nar/25.6.1272
Synthesis of the Anticodon Hairpin tRNAfMet Containing N-{[9-(β-D-Ribofuranosyl)-9H-purin-6-yl]carbamoyl}-L-threonine (=N6-{{[(1S,2R)-1-Carboxy-2-hydroxypropyl]amino}carbonyl}adenosine, t6A) Boudou, V., Langridge, J., Van Aerschot, A., Hendrix, C., Millar, A., Weiss, P. and Herdewijn, P. Helvetica Chimica Acta [details] - 10.1002/(SICI)1522-2675(20000119)83:1<152::AID-HLC
An Improved Synthesis of Inosine 3′-Phosphoramidite Jasenka Matulic-Adamic, Leonid Beigelman SYNTHETIC COMMUNICATIONS [details] - 10.1080/00397910008086956
Synthesis and Characterization of the Native Anticodon Domain of E. coli tRNALys:  Simultaneous Incorporation of Modified Nucleosides mnm5s2U, t6A, and Pseudouridine Using Phosphoramidite Chemistry Mallikarjun Sundaram, Pamela F. Crain, and Darrell R. Davis J. Org. Chem. [details] 10970299 10.1021/jo000338b
Chemical incorporation of 1‑methyladenosine into oligonucleotides Mikhailov SN, Rozenski J, Efimtseva EV et al. Nucl. Acids Res. [details] 11861902 10.1093/nar/30.5.1124
Synthesis of the tRNALys,3 Anticodon Stem-Loop Domain Containing the Hypermodified ms2t6A Nucleoside Bajji AC, Davis DR. J. Org. Chem [details] 12126427 10.1021/jo025826t
The synthesis of oligoribonucleotides containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines via post-synthetic modification of precursor oligomers. Kierzek E, Kierzek R Nucleic Acids Res [details] 12888506 -
Introduction of hypermodified nucleotides in RNA. Davis DR, Bajji AC Methods Mol Biol [details] 15333904 -
Chemical synthesis of RNA including 5-taurinomethyluridine 1. Toshihiko Ogata and 2. Takeshi Wada Nucleic Acids Symposium [details] - 10.1093/nass/nrl005

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