Modomics - A Database of RNA Modifications

General Data

RNA Type tRNA
SOTerm SO:0000268
Original Source tdbR00000312
Secondary Structure (((((((..((((....[..)))).(((((.......)))))....(((((..]....))))))))))))....
Sequence (UNICHARACTER ENCODING) GGGACCGUGRGGPAGUGGUAUCCUCUGCCGAUGGGKUCGGUAGGAC?UGAG]PBGACUCUCAGCGGUCCCACCA
Sequence (SHORT NAMES ENCODING) GGGACCGUGpm2,2GGGpYAGUGGUAUCCUCUGCCGAUGGGpm1GUCGGUAGGACpm5CUGAGpm1YpYpCmGACUCUCAGCGGUCCCACCA
Sequence (MODOMICS CODE ENCODING) GGGACCGUG2000022551GGG2000009551UAGUGGUAUCCUCUGCCGAUGGG2000001551GUCGGUAGGAC2000005551CUGAG2000019551U2000009551U2000090551CGACUCUCAGCGGUCCCACCA
Consensus Secondary Structure .(((((((..((((......[....)))).(((((.......)))))........................(((((..]....))))))))))))....
Alignment with Modification -GGGACCGUGRGGPAGU--GGU--AUCCUCUGCCGAUGGGKUCGGUAGGAC--------------------?UGAG]PBGACUCUCAGCGGUCCCACCA

Score Table

Table containing the score explanation. Score identify the level of experimental reliability and evidence so as exaplained in the 2023 release manuscript. Class 1 should be considered as highlyrelevant. Class 2 evidences are considered as Solid, namely large errors are unlikely and minor errors should not undermine the meaning of data. Class 3 is considered as speculative and errors are expected. Class 4 is considered as questionable. Class 5 evidence means that verification and data are still to be collected. Class 6 data cannot be estimated.
Method Classification Score
Multiple direct experimental evidence 1
Direct experimental evidence 2
Inferred based on indirect experimental evidence 3
Predicted computationally 4
Evidence not yet annotated (Unknown) 5
Irrelevant 6

RNA-2D Representation

RNA Secondary Structure

RNA Consensus Secondary Structure

Modification Positions

Table containing the original modifications present in the MODOMICS sequences. Edit locations not originally present in the RNA sequences are marked by their source. Their scores are in third row.

Position in the alignment 10 13 37 49 54 55 56
Position in the sequence 10 13 36 47 52 53 54
Modification positions m2,2G Y m1G m5C m1Y Y Cm
Source MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS

Modification Annotation

Table containing the data present in the literature relating to the modification positions present in the RNA sequences. Some of the modified residuals may differ from the modifications originally present in MODOMICS. It follows the same format as the previous table. The table reports the scores that have been associated to the modified nucleotides so to have an estimation of the reliability of their presence.
Position in the alignment 10 13 37 49 54 55 56
Position in the sequence 10 13 36 47 52 53 54
Source: 6746655 m2,2G Y m1G m5C m1Y Y Cm
Level of Experimental Reliability 3 3 3 3 3 3 3
Level of Experimental Evidence 3 3 3 3 3 3 3