General Data

RNA Type	mRNA
Original Source	Sci-ModoM
Transcript ID:	ENST00000409970
Gene ID:	ENSG00000105928
Gene Name:	GSDME
Sequence (UNICHARACTER ENCODING)	CCCGCCGGCCCAGCGCAGGCUCCUCCGACUCCGCCAGCGCAGGGGGCGCGGCUGCCGGGGACCCAGCAGCGGGCGCGCGGUGGUCGUGGAGUCGGACUUUGUGAAAUACGAGGGCAAGUUUGCAAACCACGUGAGUGGAACCCUGGAGACUGCACUGGGGAAGGUCAAGCUGAACCUGGGGGGCAGCAGCCGCGUAGAGAGCCAGUCUUCAUUUGGAACCCUGAGGAAGCAGGAGGUGGAUUUGCAGCAGCUCAUCAGAGACUCUGCCGAGAGAACAAUAAAUCUGAGAAACCCUGUGCUCCAGCAGGUGCUGGAAGGAAGGAAUGAGGUCCUGUGCGUUUUGACACAGAAGAUCACGACGAUGCAGAAGUGUGUGAUCUCUGAGCACAUGCAGGUCGAGGAGAAGUGUGGUGGCAUCGUGGGCAUCCAGACCAAGACGGUGCAGGUGUCAGCGACGGAGGAUGGGAAUGUCACCAAGGACUCCAACGUGGUGCUGGAGAUCCCAGCUGCCACCACCAUUGCCUACGGUGUCAUUGAGUUAUACGUGAAACUGGACGGCCAGUUCGAGUUCUGCCUUCUCCGAGGGAAGCAAGGUGGCUUCGAGAACAAGAAGAGAAUUGACUCUGUCUACCUGGACCCCCUGGUCUUUCGAGAGUUUGCAUUCAUAGACAUGCCAGAUGCUGCGCAUGGGAUAUCUUCCCAGGAUGGACCAUUAAGUGUUUUAAAGCAAGCGACCCUGCUCCUGGAGAGGAAUUUCCAUCCAUUUGCGGAGCUGCCUGAGCCACAACAGACAGCUUUGAGUGACAUCUUCCAGGCGGUCCUAUUUGAUGAUGAACUACUCAUGGUCCUGGAACCAGUGUGCGAUGACCUGGUCAGCGGCCUCUCGCCCACAGUGGCGGUGCUGGGGGAGCUGAAGCCCCGGCAGCAGCAGGACCUUGUGGCCUUCCUGCAGCUGGUGGGGUGCAGCUUACAGGGUGGGUGUCCGGGCCCCGAGGAUGCAGGCAGCAAGCAGCUGUUUAUGACAGCCUACUUCUUGGUCAGUGCCCUCGCAGAAAUGCCAGAUAGCGCAGCAGCUCUGCUGGGCACUUGCUGCAAACUCCAGAUCAUUCCCACACUGUGCCACUUGCUUCGUGCUCUGUCUGAUGAUGGAGUAUCUGAUCUUGAAGACCCAACCUUGACUCCCCUGAAAGAUACAGAAAGGUUUGGGAUUGUGCAGCGCUUGUUUGCCUCAGCUGACAUUAGUCUGGAGAGACUGAAGUCAUCUGUGAAAGCUGUCAUUCUGAAGGЖCUCUAAAGUCUUCCCACUGCUUCUUUGUAUAACCCUGAAUGGACUCUGUGCUUUAGGCAGAGAACAUUCAUGAUGUCAUAUGUGAACUAGAAGUACGUGUUACUGGCCAAGGCUAUUUUUCAGAЖCUGUUAAAGGUCAUAUGCACGUUAAAAGUUGACCAAUGAAAUGAAUUUACAGAACAGUUUAAGAAGUGGUGACAUUUUGCAUGAUGAAUGACCUGACUUUUAGCCACCAGGUACUCUUUAAACAGUUUUCCUUAUCAGAGGCCCUCCUGUGCUGGUGACCCAGCAUCUGAGUUAGGUUCCAGCAUGUAAAGAGCUGGGAGGGCGGAGAAUUCUUAGCAUACAUUCAGACGUUUUUUCUGCACAAUAAUAAGUCCAUCUGUCACUUGCAUUCCACUUUUUGUUACAUAGAAAGAGUCUGACCCUUUAAUCCAAAAGGUCUUUUUACAUUGUGAAUGCUGUGGGAAGGCAAUUUCUCUGCACACAAGAGGCUACGUUUUGGAAGUGAUGUAUGUUAUUUGAUGACUGAAAAUGAЖCUGUAAAUGCUCCUAGAGUAUAUUCCUCUGCUGAACAAAAUUAAACUUCAAAAAAAUCUAACAGUAACACACCCCUGCUUGGGACCCUAGCUAUAUGCAUUUUAUGUGACCUUGCCAUGCUUCAGUGAACAUACUAAUUCUAUGUCUAGCACAUGUUGAUUUCCUAUGUAUU
Sequence (SHORT NAMES ENCODING)	CCCGCCGGCCCAGCGCAGGCUCCUCCGACUCCGCCAGCGCAGGGGGCGCGGCUGCCGGGGACCCAGCAGCGGGCGCGCGGUGGUCGUGGAGUCGGACUUUGUGAAAUACGAGGGCAAGUUUGCAAACCACGUGAGUGGAACCCUGGAGACUGCACUGGGGAAGGUCAAGCUGAACCUGGGGGGCAGCAGCCGCGUAGAGAGCCAGUCUUCAUUUGGAACCCUGAGGAAGCAGGAGGUGGAUUUGCAGCAGCUCAUCAGAGACUCUGCCGAGAGAACAAUAAAUCUGAGAAACCCUGUGCUCCAGCAGGUGCUGGAAGGAAGGAAUGAGGUCCUGUGCGUUUUGACACAGAAGAUCACGACGAUGCAGAAGUGUGUGAUCUCUGAGCACAUGCAGGUCGAGGAGAAGUGUGGUGGCAUCGUGGGCAUCCAGACCAAGACGGUGCAGGUGUCAGCGACGGAGGAUGGGAAUGUCACCAAGGACUCCAACGUGGUGCUGGAGAUCCCAGCUGCCACCACCAUUGCCUACGGUGUCAUUGAGUUAUACGUGAAACUGGACGGCCAGUUCGAGUUCUGCCUUCUCCGAGGGAAGCAAGGUGGCUUCGAGAACAAGAAGAGAAUUGACUCUGUCUACCUGGACCCCCUGGUCUUUCGAGAGUUUGCAUUCAUAGACAUGCCAGAUGCUGCGCAUGGGAUAUCUUCCCAGGAUGGACCAUUAAGUGUUUUAAAGCAAGCGACCCUGCUCCUGGAGAGGAAUUUCCAUCCAUUUGCGGAGCUGCCUGAGCCACAACAGACAGCUUUGAGUGACAUCUUCCAGGCGGUCCUAUUUGAUGAUGAACUACUCAUGGUCCUGGAACCAGUGUGCGAUGACCUGGUCAGCGGCCUCUCGCCCACAGUGGCGGUGCUGGGGGAGCUGAAGCCCCGGCAGCAGCAGGACCUUGUGGCCUUCCUGCAGCUGGUGGGGUGCAGCUUACAGGGUGGGUGUCCGGGCCCCGAGGAUGCAGGCAGCAAGCAGCUGUUUAUGACAGCCUACUUCUUGGUCAGUGCCCUCGCAGAAAUGCCAGAUAGCGCAGCAGCUCUGCUGGGCACUUGCUGCAAACUCCAGAUCAUUCCCACACUGUGCCACUUGCUUCGUGCUCUGUCUGAUGAUGGAGUAUCUGAUCUUGAAGACCCAACCUUGACUCCCCUGAAAGAUACAGAAAGGUUUGGGAUUGUGCAGCGCUUGUUUGCCUCAGCUGACAUUAGUCUGGAGAGACUGAAGUCAUCUGUGAAAGCUGUCAUUCUGAAGGm6ACUCUAAAGUCUUCCCACUGCUUCUUUGUAUAACCCUGAAUGGACUCUGUGCUUUAGGCAGAGAACAUUCAUGAUGUCAUAUGUGAACUAGAAGUACGUGUUACUGGCCAAGGCUAUUUUUCAGAm6ACUGUUAAAGGUCAUAUGCACGUUAAAAGUUGACCAAUGAAAUGAAUUUACAGAACAGUUUAAGAAGUGGUGACAUUUUGCAUGAUGAAUGACCUGACUUUUAGCCACCAGGUACUCUUUAAACAGUUUUCCUUAUCAGAGGCCCUCCUGUGCUGGUGACCCAGCAUCUGAGUUAGGUUCCAGCAUGUAAAGAGCUGGGAGGGCGGAGAAUUCUUAGCAUACAUUCAGACGUUUUUUCUGCACAAUAAUAAGUCCAUCUGUCACUUGCAUUCCACUUUUUGUUACAUAGAAAGAGUCUGACCCUUUAAUCCAAAAGGUCUUUUUACAUUGUGAAUGCUGUGGGAAGGCAAUUUCUCUGCACACAAGAGGCUACGUUUUGGAAGUGAUGUAUGUUAUUUGAUGACUGAAAAUGAm6ACUGUAAAUGCUCCUAGAGUAUAUUCCUCUGCUGAACAAAAUUAAACUUCAAAAAAAUCUAACAGUAACACACCCCUGCUUGGGACCCUAGCUAUAUGCAUUUUAUGUGACCUUGCCAUGCUUCAGUGAACAUACUAAUUCUAUGUCUAGCACAUGUUGAUUUCCUAUGUAUU
Sequence (MODOMICS CODE ENCODING)	CCCGCCGGCCCAGCGCAGGCUCCUCCGACUCCGCCAGCGCAGGGGGCGCGGCUGCCGGGGACCCAGCAGCGGGCGCGCGGUGGUCGUGGAGUCGGACUUUGUGAAAUACGAGGGCAAGUUUGCAAACCACGUGAGUGGAACCCUGGAGACUGCACUGGGGAAGGUCAAGCUGAACCUGGGGGGCAGCAGCCGCGUAGAGAGCCAGUCUUCAUUUGGAACCCUGAGGAAGCAGGAGGUGGAUUUGCAGCAGCUCAUCAGAGACUCUGCCGAGAGAACAAUAAAUCUGAGAAACCCUGUGCUCCAGCAGGUGCUGGAAGGAAGGAAUGAGGUCCUGUGCGUUUUGACACAGAAGAUCACGACGAUGCAGAAGUGUGUGAUCUCUGAGCACAUGCAGGUCGAGGAGAAGUGUGGUGGCAUCGUGGGCAUCCAGACCAAGACGGUGCAGGUGUCAGCGACGGAGGAUGGGAAUGUCACCAAGGACUCCAACGUGGUGCUGGAGAUCCCAGCUGCCACCACCAUUGCCUACGGUGUCAUUGAGUUAUACGUGAAACUGGACGGCCAGUUCGAGUUCUGCCUUCUCCGAGGGAAGCAAGGUGGCUUCGAGAACAAGAAGAGAAUUGACUCUGUCUACCUGGACCCCCUGGUCUUUCGAGAGUUUGCAUUCAUAGACAUGCCAGAUGCUGCGCAUGGGAUAUCUUCCCAGGAUGGACCAUUAAGUGUUUUAAAGCAAGCGACCCUGCUCCUGGAGAGGAAUUUCCAUCCAUUUGCGGAGCUGCCUGAGCCACAACAGACAGCUUUGAGUGACAUCUUCCAGGCGGUCCUAUUUGAUGAUGAACUACUCAUGGUCCUGGAACCAGUGUGCGAUGACCUGGUCAGCGGCCUCUCGCCCACAGUGGCGGUGCUGGGGGAGCUGAAGCCCCGGCAGCAGCAGGACCUUGUGGCCUUCCUGCAGCUGGUGGGGUGCAGCUUACAGGGUGGGUGUCCGGGCCCCGAGGAUGCAGGCAGCAAGCAGCUGUUUAUGACAGCCUACUUCUUGGUCAGUGCCCUCGCAGAAAUGCCAGAUAGCGCAGCAGCUCUGCUGGGCACUUGCUGCAAACUCCAGAUCAUUCCCACACUGUGCCACUUGCUUCGUGCUCUGUCUGAUGAUGGAGUAUCUGAUCUUGAAGACCCAACCUUGACUCCCCUGAAAGAUACAGAAAGGUUUGGGAUUGUGCAGCGCUUGUUUGCCUCAGCUGACAUUAGUCUGGAGAGACUGAAGUCAUCUGUGAAAGCUGUCAUUCUGAAGG2000000006ACUCUAAAGUCUUCCCACUGCUUCUUUGUAUAACCCUGAAUGGACUCUGUGCUUUAGGCAGAGAACAUUCAUGAUGUCAUAUGUGAACUAGAAGUACGUGUUACUGGCCAAGGCUAUUUUUCAGA2000000006ACUGUUAAAGGUCAUAUGCACGUUAAAAGUUGACCAAUGAAAUGAAUUUACAGAACAGUUUAAGAAGUGGUGACAUUUUGCAUGAUGAAUGACCUGACUUUUAGCCACCAGGUACUCUUUAAACAGUUUUCCUUAUCAGAGGCCCUCCUGUGCUGGUGACCCAGCAUCUGAGUUAGGUUCCAGCAUGUAAAGAGCUGGGAGGGCGGAGAAUUCUUAGCAUACAUUCAGACGUUUUUUCUGCACAAUAAUAAGUCCAUCUGUCACUUGCAUUCCACUUUUUGUUACAUAGAAAGAGUCUGACCCUUUAAUCCAAAAGGUCUUUUUACAUUGUGAAUGCUGUGGGAAGGCAAUUUCUCUGCACACAAGAGGCUACGUUUUGGAAGUGAUGUAUGUUAUUUGAUGACUGAAAAUGA2000000006ACUGUAAAUGCUCCUAGAGUAUAUUCCUCUGCUGAACAAAAUUAAACUUCAAAAAAAUCUAACAGUAACACACCCCUGCUUGGGACCCUAGCUAUAUGCAUUUUAUGUGACCUUGCCAUGCUUCAGUGAACAUACUAAUUCUAUGUCUAGCACAUGUUGAUUUCCUAUGUAUU

Score Table

_{Table containing the score explanation. Score identify the level of experimental reliability and evidence so as exaplained in the 2023 release manuscript. Class 1 should be considered as highlyrelevant. Class 2 evidences are considered as Solid, namely large errors are unlikely and minor errors should not undermine the meaning of data. Class 3 is considered as speculative and errors are expected. Class 4 is considered as questionable. Class 5 evidence means that verification and data are still to be collected. Class 6 data cannot be estimated.}

Method Classification	Score
Multiple direct experimental evidence	1
Direct experimental evidence	2
Inferred based on indirect experimental evidence	3
Predicted computationally	4
Evidence not yet annotated (Unknown)	5
Irrelevant	6

Modification Positions

_{Table containing the original modifications present in the MODOMICS sequences. Edit locations not originally present in the RNA sequences are marked by their source. Their scores are in third row.}

Position in the Sequence	1287	1412	1825
Modification Positions	m6A	m6A	m6A
Genomic Coordinates	7:24699099:-	7:24698974:-	7:24698561:-
Level of Experimental Evidence	3	3	3
Level of Experimental Reliability	3	3	3
Source	Sci-ModoM	Sci-ModoM	Sci-ModoM
EUFIDs	3TeAZFYFxgvp 6AyXsheySjfx 6UuHp6YApVKv aivdrAsbdKEU Ap2q43bQLNek gZuvgwMuBfgh jNkxUQNx8GRd Mg9GixDBFQAT msuJfBpJvM5H nGifePrmgHfe NjZ8bGGJsNSR Q36pf44ZRvxu QmcpiJ88DBDn QpiKdbVikVz2 UN3tNpbCPHYf V5PvfiKsgFMd VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn 93arJtwJmuS9 nfCHyrYzE6fB BsCW7emuRX7M KENzb7mwdBd9 KjeH7Nsffuas Lny8GcCeVGc9 LZJKems7W2wi UKen6WEino9G XUkp6ghERQML dknfVe6BK8aP	3TeAZFYFxgvp 6AyXsheySjfx 6UuHp6YApVKv aivdrAsbdKEU Ap2q43bQLNek gZuvgwMuBfgh jNkxUQNx8GRd msuJfBpJvM5H NjZ8bGGJsNSR QmcpiJ88DBDn QpiKdbVikVz2 V5PvfiKsgFMd VL7zkHvkfkoB WdHxkJGRmFxn BsCW7emuRX7M KENzb7mwdBd9 KjeH7Nsffuas Lny8GcCeVGc9 LZJKems7W2wi PF5iqBNSbHaa UKen6WEino9G XUkp6ghERQML dknfVe6BK8aP	6UuHp6YApVKv jNkxUQNx8GRd msuJfBpJvM5H VL7zkHvkfkoB WdHxkJGRmFxn BsCW7emuRX7M KENzb7mwdBd9 Lny8GcCeVGc9 LZJKems7W2wi UKen6WEino9G XUkp6ghERQML dknfVe6BK8aP Mk6ShCGm6RBJ