| Name | Chronic Myeloid Leukemia (A:I) |
| Description | Upregulation of ADAR1 p-150 isoform, in the blastic crisis of CML, may be related to the activation of inflammatory pathways. An inflammatory mediator-driven isoform switch, which favors ADAR1 p150 expression, drives the expansion of malignant progenitors and contributes to CML progression. |
| Related RNA reaction | A:I |
| Found in RNA | mRNA |
| Modified Transcript | None |
| Mapping Technology | RNA-seq |
| Quantification techniques | qRT-PCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| ADAR | Double-stranded RNA-specific adenosine deaminase | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 997 | ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. | Leslie A Crews,Christian L Barrett,Hye-Jung Chun,Angela C Court,Jane M Isquith,Maria A Zipeto,Daniel J Goff,Mark Minden,Anil Sadarangani,Jessica M Rusert,Kim-Hien T Dao,Sheldon R Morris,Lawrence S B Goldstein,Marco A Marra,Kelly A Frazer, | Proc Natl Acad Sci U S A | [details] | 23275297 | 10.1073/pnas.1213021110 |