Summary:

NameGastric cancer (A:m6A)
DescriptionALKBH5 and NEAT1 are upregulated in gastric cancer. The m6A eraser ALKBH5 downregulates NEAT1 m6A levels. With decreases in NEAT1 methylation, NEAT1 is upregulated and promotes the malignant phenotype of GC by acting synergistically with EZH2
Related RNA reactionA:m6A
Found in RNAlncRNA
Modified TranscriptNEAT1
Mapping Technology
Quantification techniquesMeRIP-RT-PCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1017 ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1. Jun Zhang J Physiol Biochem [details] 31290116 10.1007/s13105-019-00690-8

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