ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. |
Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C... |
Mol Cell |
[details]
|
23177736
|
-
|
Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF-1alpha). |
Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schodel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ... |
PLoS One |
[details]
|
21264265
|
-
|
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. |
Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA... |
Nucleic Acids Res |
[details]
|
24489119
|
-
|
Crystal Structures of Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition. |
Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen Z... |
J Biol Chem |
[details]
|
24616105
|
-
|
Molecular biology. Internal mRNA methylation finally finds functions. |
Nilsen TW... |
Science |
[details]
|
24626918
|
-
|
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single stranded m6A RNA demethylation. |
Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J... |
J Biol Chem |
[details]
|
24778178
|
-
|