Summary:

NameBreast cancer (A:m6A)
Descriptionm6A inhibits breast cancer (BC) cell viability, the ability of MDA-MB-231 cells to form colonies and suppressed cell migratory abilities resulting in an overall effect of inhibition of BC growth and metastasis. Reduced expression of m6A is associated with poor prognostic in patient. Functionally, reducing m6A expression by overexpressing METTL14 and/or knockdown of ALKBH5 could inhibit breast cell viability, colony formation and cell migration.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified Transcript
Mapping Technology
Quantification techniquesELISA

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
985 Changes of N6-methyladenosine modulators promote breast cancer progression. Lianpin Wu BMC Cancer [details] 30953473 10.1186/s12885-019-5538-z

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