Summary:

NameNon-small cell lung cancer (A:m6A)
DescriptionIntermittent hipoxia (HI) promotes the expression of ALKBH5 in lung adenocarcinoma. The m6A demethylase ALKBH5 affects the proliferation and invasion of lung adenocarcinoma cells under IH by downregulating m6A modification on FOXM1 mRNA and by promoting FOXM1 expression. FOXM1 has been reported to play an important role in cell proliferation, cell cycle, cell differentiation, angiogenesis and metastasis, and also with cisplatin-based chemotherapy resistance
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptFOXM1
Mapping Technology
Quantification techniquesMeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1094 ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lungadenocarcinoma cells under intermittent hypoxia. Chao Y Biochem Biophys Res Commun [details] 31677788 S0006-291X(19)32053-4

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca