| Name | Breast cancer (A:m6A) |
| Description | m6A modification control the mRNA expression level of NANOG in some breast cancer cell lines. ALKBH5 plays critical role in mediating NANOG expression and BCSC specification and/or maintenance within the hypoxic microenvironment of human breast cancer orthotopic tumors. Mediates (together with Hypoxia-inducible factors (HIFs)) m6A demetylation of NANOG in hypoxic conditions. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | NANOG |
| Mapping Technology | |
| Quantification techniques | m6A quantification |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| ALKBH5 | RNA demethylase ALKBH5 | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 984 | Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA. | Chuanzhao Zhang | Proc Natl Acad Sci U S A | [details] | 27001847 | 10.1073/pnas.1602883113 |