Modomics - A Database of RNA Modifications


NameBreast cancer (A:m6A)
Descriptionm6A modification control the mRNA expression level of NANOG in some breast cancer cell lines. ALKBH5 plays critical role in mediating NANOG expression and BCSC specification and/or maintenance within the hypoxic microenvironment of human breast cancer orthotopic tumors. Mediates (together with Hypoxia-inducible factors (HIFs)) m6A demetylation of NANOG in hypoxic conditions.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptNANOG
Mapping Technology
Quantification techniquesm6A quantification

Enzymes connected to Breast cancer:

Acronym Full name Enzyme Role Organism Comment
ALKBH5 RNA demethylase ALKBH5 oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
984 Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA. Chuanzhao Zhang Proc Natl Acad Sci U S A [details] 27001847 10.1073/pnas.1602883113