NameBreast cancer (A:m6A)
Descriptionm6A modification control the mRNA expression level of NANOG in some breast cancer cell lines. ALKBH5 plays critical role in mediating NANOG expression and BCSC specification and/or maintenance within the hypoxic microenvironment of human breast cancer orthotopic tumors. Mediates (together with Hypoxia-inducible factors (HIFs)) m6A demetylation of NANOG in hypoxic conditions.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptNANOG
Mapping Technology
Quantification techniquesm6A quantification

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
984 Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA. Chuanzhao Zhang Proc Natl Acad Sci U S A [details] 27001847 10.1073/pnas.1602883113

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