Summary:

NameBreast cancer (A:m6A)
Descriptionm6A levels are decreased in immortalized and oncogenically transformed human mammary epithelial cells. The levels of METTL3 are descresed and ALKBH5 are increased. Overexpression of METTL3 and METTL14 and knockdown of ALKBH5 results in increased proliferation and migaration of immortalized cells. m6A levels may be downregulated in immortalized cells. Hypoxia increased m6A levels throgh mechanisms that are independent of METTL3, METTL14 and ALKBH5 expression levels. Increases of m6A levels in hypoxia are regulated by HIF.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptGlut1, Jun, VHL, Dusp1
Mapping Technology
Quantification techniquesMeRIP-PCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 Homo sapiens
METTL14 Homo sapiens
METTL3 N6-adenosine-methyltransferase 70 kDa subunit Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
983 N-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression. Nate J Fry Oncotarget [details] 30131850 10.18632/oncotarget.25782

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