Summary:

NamePancreatic cancer (A:m6A)
DescriptionALKBH5 decreases WIF-1 mRNA m6A levels and thus increases WIF protein levels. The upregulation of WIF-1 inhibits Wnt pathway and its downstream targets, leading to the inhibition of pancreatic tumorigenesis and sensitization to chemotherapy. Thus, the downregulation of ALKBH5 in pancreatic cancer, induces PDAC cell proliferation, migration, invasion, tumorigenesis, and metastasis in vitro and in vivo.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptWIF-1
Mapping TechnologyMeRIP-seq
Quantification techniquesMeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1107 mA demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling. Bo Tang Mol Cancer [details] 31906946 10.1186/s12943-019-1128-6

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