Summary:

NameLeukemia (A:m6A)
DescriptionMutations found in m6A regulatory genes are associated with lower OS and EFS rates in patients with AML ( Acute myeloid Leukemia) and presence of p53 mutations.
Related RNA reactionA:m6A
Modified Transcript
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 oncogene/tumor-suppressor Homo sapiens
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene/tumor-suppressor Homo sapiens
METTL14 oncogene/tumor-suppressor Homo sapiens
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene/tumor-suppressor Homo sapiens
YTHDF1 YTH N6-methyladenosine RNA binding protein 1 oncogene/tumor-suppressor Homo sapiens
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 oncogene/tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1062 Genetic alterations of mA regulators predict poorer survival in acute myeloid leukemia. Chau-To Kwok J Hematol Oncol [details] 28153030 10.1186/s13045-017-0410-6

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