Summary:

NameGlioblastoma (A:m6A)
DescriptionIncreased m6A methylation protects against GSCs self-renewal, proliferation and tumorigenesis. The increased ALKBH5 expression in GSCs is associated to a decreased methylation of FOXM1 pre-mRNA.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptFOXM1
Mapping TechnologyMeRIP-seq
Quantification techniquesMeRIP-qPCR, m6A quantification

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1025 m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells bySustaining FOXM1 Expression and Cell Proliferation Program. Zhang S Cancer Cell [details] 28344040 S1535-6108(17)30056-9
1026 FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Ai-Hua Gong Cancer Res [details] 25832656 10.1158/0008-5472.CAN-14-2800

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