Modomics - A Database of RNA Modifications


NameBreast cancer (A:m6A)
Description"m6A levels are reduced in breast cancer samples due to a decrease in m6A methylases expression and an increase in demethylases expression; expression levels of METTL3, METTL14, WTAP and FTO were correlated with poor survival and cancer progression; m6A higher levels suppress cancer cell viability, inhibit MDA-MB-231 colony-formation abilities and cell migratory abilities.Expression levels of writers and readers differes according to the subtype of breast cancer ( luminal A/B vs. triple negative)."
Related RNA reactionA:m6A
Modified Transcript
Mapping Technology
Quantification techniquesm6A quantification, ELISA

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
ALKBH5 Homo sapiens
FTO Alpha-ketoglutarate-dependent dioxygenase FTO Homo sapiens
METTL14 Homo sapiens
METTL3 N6-adenosine-methyltransferase 70 kDa subunit Homo sapiens
WTAP Pre-mRNA-splicing regulator WTAP Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
985 Changes of N6-methyladenosine modulators promote breast cancer progression. Lianpin Wu BMC Cancer [details] 30953473 10.1186/s12885-019-5538-z

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