| Name | Glioblastoma (A:m6A) |
| Description | Increased m6A methylation protects against GSCs self-renewal, proliferation and tumorigenesis. The increased ALKBH5 expression in GSCs is associated to a decreased methylation of FOXM1 pre-mRNA. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | FOXM1 |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | MeRIP-qPCR, m6A quantification |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| ALKBH5 | RNA demethylase ALKBH5 | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1025 | m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells bySustaining FOXM1 Expression and Cell Proliferation Program. | Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, Majumder S, He C, Huang S | Cancer Cell | [details] | 28344040 | S1535-6108(17)30056-9 |
| 1026 | FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. | Ping Wei,Sicong Zhang,Jun Yao,Ying Yuan,Ai-Dong Zhou,Frederick F Lang,Amy B Heimberger,Ganesh Rao, | Cancer Res | [details] | 25832656 | 10.1158/0008-5472.CAN-14-2800 |