Summary:

NameNeurofibromatosis (C:U)
DescriptionC-to-U editing of NF1 RNA creates a translational stop codon, potentially leading to premature truncation of neurofibromin
Related RNA reactionC:U
Found in RNAmRNA
Modified TranscriptNF1
Mapping TechnologyDirect sequencing
Quantification techniquesRT-PCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1085 C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both thetype II transcript and apobec-1, the catalytic subunit of the apolipoprotein BmRNA-editing enzyme. Mukhopadhyay D Am J Hum Genet [details] 11727199 S0002-9297(07)61281-6

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