Modomics - A Database of RNA Modifications

Full name:	apolipoprotein B mRNA editing enzyme catalytic subunit 1
Synonym:	BEDP,CDAR1,APOBEC-1,HEPR
GI:	None
Orf:	None
COG:	None
UniProt:	P41238
Structures:	\| 6x91 \|
Complex:	None

Comments:

None

Protein sequence:

MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRSSGKNTTNHVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAI
REFLSRHPGVTLVIYVARLFWHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYPPGDEAHWPQYPPLWMMLYALELHCIILSLPPCLKISRRWQ
NHLTFFRLHLQNCHYQTIPPHILLATGLIHPSVAWR

Diseases connected to this enzyme:

Description	Reaction	Disease Name
Increased C-to-U RNA editing mediated by APOBEC1 leads to neuronal gain-of-function through presynaptic activity of RNA-edited GlyRs, resulting in facilitation of neurotransmitter release	C:U	Temporal Lobe Epilepsy
C-to-U editing of NF1 RNA creates a translational stop codon, potentially leading to premature truncation of neurofibromin	C:U	Neurofibromatosis
Overexpression of APOBEC1 determines aberrant editing that could contribute to the oncogenesis	C:U	Hepatocellular carcinoma
APOBEC1 RNA editing is correlated to a reduction of atherosclerosis thanks to the presence of ApoB48 isoform	C:U	Diabetes/obesity