| Name | Temporal Lobe Epilepsy (C:U) |
| Description | Increased C-to-U RNA editing mediated by APOBEC1 leads to neuronal gain-of-function through presynaptic activity of RNA-edited GlyRs, resulting in facilitation of neurotransmitter release |
| Related RNA reaction | C:U |
| Found in RNA | mRNA |
| Modified Transcript | GLYR |
| Mapping Technology | None |
| Quantification techniques | RT-PCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| APOBEC1 | apolipoprotein B mRNA editing enzyme catalytic subunit 1 | None | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1121 | A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy. | Svenja Kankowski | Front Mol Neurosci | [details] | 29375302 | 10.3389/fnmol.2017.00439 |