|Treacher Collins syndrome (N:Nm)
|Inhibition of the production of properly modified leading to impaired proliferation and differentiation of specific embryonic cells. Downregulated expression of treacle resulted in decrease 2'-O-Me of 18S pre-rRNA
|Related RNA reaction
|Found in RNA
|18S rRNA (position C463)
|2'-O-Methyl RNA-DNA chimera directed RNase H cleavage.
|treacle ribosome biogenesis factor 1
|The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNAmethylation.
|Hum Mol Genet