Modomics - A Database of RNA Modifications

ID Card:

Full name: treacle ribosome biogenesis factor 1
Synonym: treacle,TCS
GI: 302393806
UniProt: Q13428
Alpha Fold Predicted Structure: AF-Q13428-F1



Protein sequence:

MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV

Comments:





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A E A R K R R E L L P L I Y H H L L R A G Y V R A A R E V K E Q S G Q K C F L A Q P V T L L D I Y T H W Q Q T S E L G R K R K A E E D A A L Q A K K T R V S D P I S T S E S S E E E E E A E A E T A K A T P R L A S T N S S V L G A D L P S S M K E K A K A E T E K A G K T G N S M P H P A T G K T V A N L L S G K S P R K S A E P S A N T T L V S E T E E E G S V P A F G A A A K P G M V S A G Q A D S S S E D T S S S S D E T D V E G K P S V K P A Q V K A S S V S T K E S P A R K A A P A P G K V G D V T P Q V K G G A L P P A K R A K K P E E E S E S S E E G S E S E E E A P A G T R S Q V K A S E K I L Q V R A A S A P A K G T P G K G A T P A P P G K A G A V A S Q T K A G K P E E D S E S S S E E S S D S E E E T P A A K A L L Q A K A S G K T S Q V G A A S A P A K E S P R K G A A P A P P G K T G P A V A K A Q A G K R E E D S Q S S S E E S D S E E E A P A Q A K P S G K A P Q V R A A S A P A K E S P R K G A A P A P P R K T G P A A A Q V Q V G K Q E E D S R S S S E E S D S D R E A L A A M N A A Q V K P L G K S P Q V K P A S T M G M G P L G K G A G P V P P G K V G P A T P S A Q V G K W E E D S E S S S E E S S D S S D G E V P T A V A P A Q E K S L G N I L Q A K P T S S P A K G P P Q K A G P V A V Q V K A E K P M D N S E S S E E S S D S A D S E E A P A A M T A A Q A K P A L K I P Q T K A C P K K T N T T A S A K V A P V R V G T Q A P R K A G T A T S P A G S S P A V A G G T Q R P A E D S S S S E E S D S E E E K T G L A V T V G Q A K S V G K G L Q V K A A S V P V K G S L G Q G T A P V L P G K T G P T V T Q V K A E K Q E D S E S S E E E S D S E E A A A S P A Q V K T S V K K T Q A K A N P A A A R A P S A K G T I S A P G K V V T A A A Q A K Q R S P S K V K P P V R N P Q N S T V L A R G P A S V P S V G K A V A T A A Q A Q T G P E E D S G S S E E E S D S E E E A E T L A Q V K P S G K T H Q I R A A L A P A K E S P R K G A A P T P P G K T G P S A A Q A G K Q D D S G S S S E E S D S D G E A P A A V T S A Q V I K P P L I F V D P N R S P A G P A A T P A Q A Q A A S T P R K A R A S E S T A R S S S S E S E D E D V I P A T Q C L T P G I R T N V V T M P T A H P R I A P K A S M A G A S S S K E S S R I S D G K K Q E G P A T Q V S K K N P A S L P L T Q A A L K V L A Q K A S E A Q P P V A R T Q P S S G V D S A V G T L P A T S P Q S T S V Q A K G T N K L R K P K L P E V Q Q A T K A P E S S D D S E D S S D S S S G S E E D G E G P Q G A K S A H T L G P T P S R T E T L V E E T A A E S S E D D V V A P S Q S L L S G Y M T P G L T P A N S Q A S K A T P K L D S S P S V S S T L A A K D D P D G K Q E A K P Q Q A A G M L S P K T G G K E A A S G T T P Q K S R K P K K G A G N P Q A S T L A L Q S N I T Q C L L G Q P W P L N E A Q V Q A S V V K V L T E L L E Q E R K K V V D T T K E S S R K G W E S R K R K L S G D Q P A A R T P R S K K K K K L G A G E G G E A S V S P E K T S T T S K G K A K R D K A S G D V K E K K G K G S L G S Q G A K D E P E E E L Q K G M G T V E G G D Q S N P K S K K E K K K S D K R K K D K E K K E K K K K A K K A S T K D S E S P S Q K K K K K K K K T A E Q T V

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q13428-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q13428-F1.cif  
DSSP Secondary Structures   Q13428.dssp  





Diseases connected to this enzyme:

Description Reaction Disease Name
Inhibition of the production of properly modified leading to impaired proliferation and differentiation of specific embryonic cells. Downregulated expression of treacle resulted in decrease 2'-O-Me of 18S pre-rRNA N:Nm
Treacher Collins syndrome

Publications:

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