| Name | Bladder cancer (A:m6A) |
| Description | m6A modification and METTL14 are lowly expressed in bladder cancer. METTL14 and m6A modification participate in the RNA stability of Notch1 mRNA. Notch1 m6A modification inhibits its RNA stability. Notch1 plays an essential role in bladder tumorigenesis and bladder tumor initiating cells self-renewal |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | Notch1 |
| Mapping Technology | |
| Quantification techniques | m6A dot blot assay |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit | tumor-supressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 976 | Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N-methyladenosine of Notch1. | Chaohui Gu | Mol Cancer | [details] | 31760940 | 10.1186/s12943-019-1084-1 |