NameBladder cancer (A:m6A)
Descriptionm6A modification and METTL14 are lowly expressed in bladder cancer. METTL14 and m6A modification participate in the RNA stability of Notch1 mRNA. Notch1 m6A modification inhibits its RNA stability. Notch1 plays an essential role in bladder tumorigenesis and bladder tumor initiating cells self-renewal
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptNotch1
Mapping Technology
Quantification techniquesm6A dot blot assay

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL14 tumor-supressor Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
976 Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N-methyladenosine of Notch1. Chaohui Gu Mol Cancer [details] 31760940 10.1186/s12943-019-1084-1

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca