| Name | Breast cancer (A:m6A) |
| Description | m6A inhibits breast cancer (BC) cell viability, the ability of MDA-MB-231 cells to form colonies and suppressed cell migratory abilities resulting in an overall effect of inhibition of BC growth and metastasis. Reduced expression of m6A is associated with poor prognostic in patient. Functionally, reducing m6A expression by overexpressing METTL14 and/or knockdown of ALKBH5 could inhibit breast cell viability, colony formation and cell migration. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | |
| Mapping Technology | |
| Quantification techniques | ELISA |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 985 | Changes of N6-methyladenosine modulators promote breast cancer progression. | Lianpin Wu | BMC Cancer | [details] | 30953473 | 10.1186/s12885-019-5538-z |