| Name | Colorectal cancer (A:m6A) |
| Description | METTL14 is downregulated in CRC tissues and cell lines. It reduces m6A levels in total RNAs and promotes CRC cell growth and metastasis, METTL14 decreases miR-375 expression levels by modulating DGCR8 binding to primary miR-375 (primiR-375) in a m6A-dependent manner. |
| Related RNA reaction | A:m6A |
| Found in RNA | miRNA |
| Modified Transcript | miR-375 |
| Mapping Technology | |
| Quantification techniques | m6A quantification, MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 999 | METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-DependentPrimary miR-375 Processing. | Chen X | Mol Ther | [details] | 31839484 | S1525-0016(19)30512-X |