Summary:

NameColorectal cancer (A:m6A)
DescriptionMETTL14 is downregulated in CRC tissues and cell lines. It reduces m6A levels in total RNAs and promotes CRC cell growth and metastasis, METTL14 decreases miR-375 expression levels by modulating DGCR8 binding to primary miR-375 (primiR-375) in a m6A-dependent manner.
Related RNA reactionA:m6A
Found in RNAmiRNA
Modified TranscriptmiR-375
Mapping Technology
Quantification techniquesm6A quantification, MeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL14 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
999 METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-DependentPrimary miR-375 Processing. Chen X Mol Ther [details] 31839484 S1525-0016(19)30512-X

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