| Name | Colorectal cancer (A:m6A) |
| Description | The overexpressed YTHDF1, associated to DNA copy number gain, recognizes and promotes the translation of m6A-modified FZD9 and Wnt6 mRNAs, leading to an aberrant activation of Wnt/b-catenin signaling and ultimately affecting the tumorigenicity and stem cell-like activity in CRC. Epigenetic regulation by YTHDF1 plays an important role in cancer progression processes in CRC. In another study, it was demonstrated that YTHDF1 overexpression is promoted by c-Myc and is associated to CRC cells proliferation and chemoresistence. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | Wnt/b-catenin pathway |
| Mapping Technology | |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| YTHDF1 | YTH N6-methyladenosine RNA binding protein 1 | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1381 | Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. | Yujiro Nishizawa,Masamitsu Konno,Ayumu Asai,Jun Koseki,Koichi Kawamoto,Norikatsu Miyoshi,Hidekazu Takahashi,Naohiro Nishida,Naotsugu Haraguchi,Daisuke Sakai,Toshihiro Kudo,Taishi Hata,Chu Matsuda,Tsunekazu Mizushima,Taroh Satoh,Yuichiro Doki,Masaki Mori,Hideshi Ishii | Oncotarget | [details] | 29484125 | - |
| 1382 | YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma | Y Bai, C Yang, R Wu, L Huang, S Song, W Li, P Yan, C Lin, D Li, Y Zhang | Front Oncol. | [details] | 31131257 | 10.3389/fonc.2019.00332 |