Summary:

NameColorectal cancer (A:m6A)
DescriptionThe overexpressed YTHDF1, associated to DNA copy number gain, recognizes and promotes the translation of m6A-modified FZD9 and Wnt6 mRNAs, leading to an aberrant activation of Wnt/b-catenin signaling and ultimately affecting the tumorigenicity and stem cell-like activity in CRC. Epigenetic regulation by YTHDF1 plays an important role in cancer progression processes in CRC. In another study, it was demonstrated that YTHDF1 overexpression is promoted by c-Myc and is associated to CRC cells proliferation and chemoresistence.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptWnt/b-catenin pathway
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF1 YTH N6-methyladenosine RNA binding protein 1 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1381 Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. Yujiro Nishizawa Oncotarget [details] 29484125 -
1382 YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma Y Bai Front Oncol. [details] 31131257 10.3389/fonc.2019.00332

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