| Name | Depression disorder (A:I) |
| Description | RNA editing inhibits the enzymatic activity of TPH2 splice variants. Deregulated alternative splicing and RNA editing are involved in the etiology of psychiatric diseases, such as suicidal behavior. |
| Related RNA reaction | A:I |
| Found in RNA | mRNA |
| Modified Transcript | TPH2b |
| Mapping Technology | exone sequencing |
| Quantification techniques | HPLC |
| Acronym | Full name | Enzyme Role | Organism | Comment | Exact modification enzyme yet to be verified. One or more ADAR enzymes involved, putatively. |
|---|
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1008 | Alternative splicing and extensive RNA editing of human TPH2 transcripts. | Maik Grohmann | PLoS One | [details] | 20126463 | 10.1371/journal.pone.0008956 |