Summary:

NameHepatocellular carcinoma (A:m6A)
Descriptionm6A methylation of pri-miR126 enhances its recogntion by DGCR8 and its subsequent processing to mature miRNA. miR126 plays an important role in tumor metastasis by acting as a tumor suppressor. The downregulation of METTL14 in HCC cells leads to the decreased processing of pri-miR126 thus reducing its tumor-suppressor activity
Related RNA reactionA:m6A
Found in RNAmiRNA
Modified TranscriptmiR126
Mapping Technology
Quantification techniquesm6A dot blot assay, m6A immunoblotting

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL14 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1040 METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N -methyladenosine-dependent primary MicroRNA processing. Jin-Zhao Ma Hepatology [details] 27774652 10.1002/hep.28885

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca