| Name | Leukemia (A:m6A) |
| Description | METTL14 is highly expressed in normal hematopoietic stem/progenitor cells (HSPCs) and acute myeloid leukemia (AML) cells carrying t(11q23), t(15;17), or t(8;21), and is down-regulated during myeloid differentiation. Mechanistically, METTL14 exerts its oncogenic role by regulating its mRNA targets (e.g., MYB and MYC) through m6A modification, which in turn leads to enhanced self-renewal/proliferation of LSCs/LICs and blockage of myeloid differentiation |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | MYB, MYC |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | LC-MS/MS |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1068 | METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and PromotesLeukemogenesis via mRNA m(6)A Modification. | Weng H | Cell Stem Cell | [details] | 29290617 | S1934-5909(17)30468-X |