| Name | Leukemia (A:m6A) |
| Description | METTL14 is highly expressed in normal hematopoietic stem/progenitor cells (HSPCs) and acute myeloid leukemia (AML) cells carrying t(11q23), t(15;17), or t(8;21), and is down-regulated during myeloid differentiation. Mechanistically, METTL14 exerts its oncogenic role by regulating its mRNA targets (e.g., MYB and MYC) through m6A modification, which in turn leads to enhanced self-renewal/proliferation of LSCs/LICs and blockage of myeloid differentiation |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | MYB, MYC |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | LC-MS/MS |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1068 | METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and PromotesLeukemogenesis via mRNA m(6)A Modification. | Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J | Cell Stem Cell | [details] | 29290617 | S1934-5909(17)30468-X |