Summary:

NameMelanoma (A:m6A)
DescriptionDecreased m6A levels are identified in ocular melanoma samples, indicating poor prognosis, and changes in global m6A modification are highly associated with tumor progression. Mechanistically, YTHDF1 promotes the translation of methylated mRNA of HINT2, a tumor suppressor in ocular melanoma.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptHINT2
Mapping TechnologymiCLIP-seq, MeRIP-seq
Quantification techniquesMeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF1 YTH N6-methyladenosine RNA binding protein 1 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1077 mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation. Ruobing Jia Mol Cancer [details] 31722709 10.1186/s12943-019-1088-x

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