| Name | Melanoma (A:m6A) |
| Description | Decreased m6A levels are identified in ocular melanoma samples, indicating poor prognosis, and changes in global m6A modification are highly associated with tumor progression. Mechanistically, YTHDF1 promotes the translation of methylated mRNA of HINT2, a tumor suppressor in ocular melanoma. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | HINT2 |
| Mapping Technology | miCLIP-seq, MeRIP-seq |
| Quantification techniques | MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| YTHDF1 | YTH N6-methyladenosine RNA binding protein 1 | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1077 | mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation. | Ruobing Jia | Mol Cancer | [details] | 31722709 | 10.1186/s12943-019-1088-x |