| Name | Non-small cell lung cancer (A:m6A) |
| Description | Intermittent hipoxia (HI) promotes the expression of ALKBH5 in lung adenocarcinoma. The m6A demethylase ALKBH5 affects the proliferation and invasion of lung adenocarcinoma cells under IH by downregulating m6A modification on FOXM1 mRNA and by promoting FOXM1 expression. FOXM1 has been reported to play an important role in cell proliferation, cell cycle, cell differentiation, angiogenesis and metastasis, and also with cisplatin-based chemotherapy resistance |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | FOXM1 |
| Mapping Technology | |
| Quantification techniques | MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| ALKBH5 | RNA demethylase ALKBH5 | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1094 | ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lungadenocarcinoma cells under intermittent hypoxia. | Chao Y | Biochem Biophys Res Commun | [details] | 31677788 | S0006-291X(19)32053-4 |