| Name | Pancreatic cancer (A:m6A) |
| Description | ALKBH5 decreases WIF-1 mRNA m6A levels and thus increases WIF protein levels. The upregulation of WIF-1 inhibits Wnt pathway and its downstream targets, leading to the inhibition of pancreatic tumorigenesis and sensitization to chemotherapy. Thus, the downregulation of ALKBH5 in pancreatic cancer, induces PDAC cell proliferation, migration, invasion, tumorigenesis, and metastasis in vitro and in vivo. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | WIF-1 |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| ALKBH5 | RNA demethylase ALKBH5 | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1107 | mA demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling. | Bo Tang | Mol Cancer | [details] | 31906946 | 10.1186/s12943-019-1128-6 |