| Name | Renal cell carcinoma (A:m6A) |
| Description | Increased P2RX6 mRNA m6A methylation level (induced by METTL14) enhances P2RX6 pre-mRNA splicing, decreases ATP-P2RX6-Ca2+ −p-ERK1/2-MMP9 axis and protects against RCCs migration and invasion. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | P2RX6 |
| Mapping Technology | |
| Quantification techniques | m6A quantification |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1115 | The mA-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. | Jin Zhang,Yonghui Chen,Yunfei Xu,Junjie Ma,Guanghui Hu,Yiran Huang,Junhua Zheng,Wei Zhai, | J Exp Clin Cancer Res | [details] | 31159832 | 10.1186/s13046-019-1223-y |