Summary:

NameRenal cell carcinoma (A:m6A)
DescriptionIncreased P2RX6 mRNA m6A methylation level (induced by METTL14) enhances P2RX6 pre-mRNA splicing, decreases ATP-P2RX6-Ca2+ −p-ERK1/2-MMP9 axis and protects against RCCs migration and invasion.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptP2RX6
Mapping Technology
Quantification techniquesm6A quantification

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL14 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1115 The mA-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. Dongkui Gong J Exp Clin Cancer Res [details] 31159832 10.1186/s13046-019-1223-y

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