| Name | Type 2 Diabetes (A:m6A) |
| Description | METTL3 and METTL14 protein levels are decreased in whole islets from T2D patients. the Insulin/IGF1 -AKT-PDX1 pathway is significantly affected by hypomethylation in T2D |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | Insulin/IGF1 -AKT-PDX1 pathway |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | LC-MS/MS |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit | Homo sapiens | ||
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1124 | mA mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes. | Zijie Zhang,Sevim Kahraman,Natalie K Brown,Mengjie Chen,Jiang Hu,Manoj K Gupta,Chuan He, | Nat Metab | [details] | 31867565 | 10.1038/s42255-019-0089-9 |