The molecule is shown in a ball-and-stick representation with the
following colors for atoms :
⬤ Hydrogen (H): white
⬤ Carbon (C): gray
⬤ Oxygen (O): red
⬤ Phosphorus (P): orange
⬤ Nitrogen (N): blue
⬤ Selenium (Se): gold
⬤ Sulfur (S): yellow
Summary
| Full name | 2-geranylthiouridine |
| Short name | ges2U |
| MODOMICS code new | 2000000021U |
| MODOMICS code | 21U |
| Nature of the modified residue | Natural |
| RNAMods code | Γ |
| Residue unique ID | 166 |
| Found in RNA | Yes |
| Related nucleotides | 373 |
| Enzymes |
MnmH (Escherichia coli)
|
| Found in phylogeny | Eubacteria |
Chemical information
| Sum formula | C19H28N2O5S |
| Type of moiety | nucleoside |
| Degeneracy | not applicable |
| SMILES | CC(C)=CCC/C(/C)=C/CSc1nc(=O)cc[n]1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
| logP | 1.6396 |
| TPSA | 130.11 |
| Number of atoms | 27 |
| Number of Hydrogen Bond Acceptors 1 (HBA1) | 7 |
| Number of Hydrogen Bond Acceptors 2 (HBA2) | 8 |
| Number of Hydrogen Bond Donors (HBD) | 3 |
| PDB no exac match , link to the most similar ligand |
URI |
| HMDB (Human Metabolome Database) no exact match, link to the most similar ligand |
None |
| InChI | InChI=1S/C19H28N2O5S/c1-12(2)5-4-6-13(3)8-10-27-19-20-15(23)7-9-21(19)18-17(25)16(24)14(11-22)26-18/h5,7-9,14,16-18,22,24-25H,4,6,10-11H2,1-3H3/b13-8+/t14-,16-,17-,18-/m1/s1 |
| InChIKey | KFZLIRUEFHTLEW-ZGFVZBPKSA-N |
| Search the molecule in external databases |
ChEMBL
ChemAgora
ChEBI
PubChem Compound Database
Ligand Expo
ChemSpider
WIPO
|
* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)
Download Structures
Tautomers
| Tautomers SMILES |
CC(C)=CCCC(C)=CCSc1nc(=O)ccn1C2OC(CO)C(O)C2O tautomer #0
|
| Tautomer image |
Show Image
|
Predicted CYP Metabolic Sites
* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)
LC-MS Information
| Monoisotopic mass | 396.1719 |
| Average mass | 396.501 |
| [M+H]+ | 397.1797 |
| Product ions | 265 |
| Normalized LC elution time * | not available |
| LC elution order/characteristics | not available |
* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.
Comments
An intermediate in the synthesis of cmnm5ges2U and mnm5ges2U.
Chemical groups contained
| Type | Subtype |
|---|
| sulphur | thio |
| hydrocarbon | geranyl |
Reactions producing 2-geranylthiouridine
Reactions starting from 2-geranylthiouridine
Publications
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Discovery and biological characterization of geranylated RNA in bacteria. |
Dumelin CE, Chen Y, Leconte AM, Chen YG, Liu DR... |
Nat Chem Biol |
[details]
|
22983156
|
-
|
| A gain of function mutation in a protein mediates production of novel modified nucleosides. |
Chen P, Crain PF, Nasvall SJ, Pomerantz SC, Bjork GR... |
EMBO J |
[details]
|
15861125
|
-
|
Last modification of this entry: Sept. 22, 2023
